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Determine 1 Synthesis and degradation of ACh. ACh is synthesized from Acetyl-S-CoA and choline from the choline acetyltransferase (ChAT) enzyme from the cytoplasm. ACh is secreted out promptly after synthesis in non-immune cells but stored in a very specialised vesicle in neuronal cells secreted at presynaptic neurons after activation. Release of A
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